Planning a trip to South Carolina? With major metro areas such as Columbia and Charleston, along with top attractions including Brookgreen Gardens, Fort Sumter and Middleton Place, you are sure to have a unique and memorable experience. Take in all the great sights that South Carolina has to offer with a hire car from Enterprise Rent-A-Car. Choose from one of our popular airport locations or find the perfect car at a neighbourhood branch. Search for a car rental location or browse the list below.